HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexyl chloroformate → ethyl 3-[[2-[2-[4-(N-hexoxycarbonylcarbamimidoyl)phenyl]ethyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexyl chloroformate | HCID 22466 | — |
| Reactant | HCID 18412669 | HCID 18412669 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | ethyl 3-[[2-[2-[4-(N-hexoxycarbonylcarbamimidoyl)phenyl]ethyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate | HCID 140409599 | 72% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[2-(4-amidinophenyl)ethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-hexyl chloroformate. Yield: 72% of theory, C35H42N6O5 (626.8); Rf value: 0.54 (silica gel; dichloromethane/methanol=9:1); EKA mass spectrum: (M+H)+=627; (M+Na)+=649.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-27fa37c786e047c5b787eed886f0a434 |
| Source note | uspto-grants-2004_03 |