HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nicotinoyl chloride → HCID 140409608, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nicotinoyl chloride | HCID 82604 | — |
| Reactant | 1-methyl-2-[2-(4-amidinophenyl)ethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride | HCID 18412669 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 140409608 | HCID 140409608 | 56% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[2-(4-amidinophenyl)ethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and nicotinic acid chloride. Yield: 56% of theory, C34H33N7O4 (603.7); Rf value: 0.52 (silica gel; dichloromethane/methanol=9:1); EKA mass spectrum: (M+H)+=604; (M+Na)+=626.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-0604abb1cffe45d6a5bf2b5525201294 |
| Source note | uspto-grants-2004_03 |