HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonochloridic acid, octyl ester → ethyl 3-(N-[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]anilino)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonochloridic acid, octyl ester | HCID 81956 | — |
| Reactant | 1-Methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylicacid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide-hydrochloride | HCID 18412553 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | ethyl 3-(N-[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]anilino)propanoate | HCID 140409593 | 34% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-octyl chloroformate. Yield: 34% of theory, C37H46N6O5 (654.8); Rf value: 0.15 (silica gel; dichloromethane/ethanol=19:1); EKA mass spectrum: (M+H)+=655; (M+H+Na)++=339; (M+Na)+=677.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-82816fe5f5c542a591c9b4e33d707084 |
| Source note | uspto-grants-2004_03 |