HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 503560Generated: October 31, 2026
1-Chloro-4-phenylphthalazine → N1-(7-methoxy-1,5-naphthyridin-4-yl)-N1-methyl-N4-(4-phenylphthalazin-1-yl)benzene-1,4-diamine
https://huagongshe.com/reaction/503560
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Chloro-4-phenylphthalazine | HCID 272109 | — |
| Reactant | HCID 67317033 | HCID 67317033 | — |
| Product | N1-(7-methoxy-1,5-naphthyridin-4-yl)-N1-methyl-N4-(4-phenylphthalazin-1-yl)benzene-1,4-diamine | HCID 59427356 | — |
Reaction Steps
A mixture of N1-(7-methoxy-1,5-naphthyridin-4-yl)-N1-methylbenzene-1,4-diamine (0.061 g, 0.22 mmol) and 1-chloro-4-phenylphthalazine (0.052 g, 0.22 mmol) was heated at 100° C. for 48 h. The solvent was removed in vacuo and the residue was purified by silica gel chromatography using 1-10% MeOH:CH2Cl2 containing 1% NH4OH to afford N1-(7-methoxy-1,5-naphthyridin-4-yl)-N1-methyl-N4-(4-phenylphthalazin-1-yl)benzene-1,4-diamine as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07776857B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-0fe5e6c588114134ac5a0c8802a3312d |
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| Source note | uspto-grants-2010_08 |
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