Sodium Hydroxide → HCID 18412456, compound

HRID 50361Notes

Reaction equation

HRID 50361 reaction equation
Cl.[C:2]1([N:8]([CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])[S:9]([C:12]2[CH:32]=[CH:31][C:15]3[N:16]([CH3:30])[C:17]([CH2:19][NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27](=[NH:29])[NH2:28])=[CH:23][CH:22]=4)=[N:18][C:14]=3[CH:13]=2)(=[O:11])=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[C:2]1([N:8]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])[S:9]([C:12]2[CH:32]=[CH:31][C:15]3[N:16]([CH3:30])[C:17]([CH2:19][NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27](=[NH:28])[NH2:29])=[CH:23][CH:22]=4)=[N:18][C:14]=3[CH:13]=2)(=[O:11])=[O:10])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18412309HCID 18412309, compound

Product 1

HCID 18412456HCID 18412456, compoundYield 24%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-sulfonic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride and sodium hydroxide solution. Yield: 24% of theory, C25H26N6O4S (506.6); Rf value: 0.55 (Reverse-Phase RP-18 silica gel; methanol/5% saline solution=3:2); EKA mass spectrum: (M+H)+=507; (M+Na)+=529; (M+2Na)++=276.

Sources & evidence

ORD record
ord-074d819e67f24408930f903c302099c6
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

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