HRID503637

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cn1cc[c]([Sn]([CH3])([CH3])[CH3])cc1=O

HCID67317779

未命名化合物

结构：COc1cnc2c(Sc3ccc(Nc4nnc(Cl)c5ccccc45)cc3)ccnc2c1

HCID86628664

未命名化合物

PRODUCTS

生成物

结构：COc1cnc2c(Sc3ccc(Nc4nnc(-c5ccn(C)c(=O)c5)c5ccccc45)cc3)ccnc2c1

HCID59427299

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID1140

Toluene

C7H8

CONDITIONS

反应条件

温度: 100 °C

PROCEDURE

实验过程

4-Chloro-N-(4-(7-methoxy-1,5-naphthyridin-4-ylthio)phenyl)phthalazin-1-amine (148 mg, 331 μmol),1-methyl-4-(trimethylstannyl)pyridin-2(1H)-one (90 mg, 331 μmol), and the Pd catalyst were added to toluene and heated to 100° C. for 2 h. The mixture was concentrated and purified by silica gel chromatography using 0 to 30% MeOH in ethyl acetate. MS: M+H+=519.

WORKUP

后处理

concentrationThe mixture was concentrated
custompurified by silica gel chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-609fb2aa4d744c6393856dd790225952
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07776857B2
来源说明: uspto-grants-2010_08

反应 SMILES

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([S:19][C:20]3[C:29]4[C:24](=[CH:25][C:26]([O:30][CH3:31])=[CH:27][N:28]=4)[N:23]=[CH:22][CH:21]=3)=[CH:15][CH:14]=2)=[N:4][N:3]=1.[CH3:32][N:33]1[CH:38]=[CH:37][C:36]([Sn](C)(C)C)=[CH:35][C:34]1=[O:43]>[Pd].C1(C)C=CC=CC=1>[CH3:31][O:30][C:26]1[CH:25]=[C:24]2[C:29]([C:20]([S:19][C:16]3[CH:17]=[CH:18][C:13]([NH:12][C:5]4[C:6]5[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=5)[C:2]([C:36]5[CH:37]=[CH:38][N:33]([CH3:32])[C:34](=[O:43])[CH:35]=5)=[N:3][N:4]=4)=[CH:14][CH:15]=3)=[CH:21][CH:22]=[N:23]2)=[N:28][CH:27]=1