反应详情

温度

100 °C

In a 20 mL sealed tube, was added 1,4-dioxane (1.08 mL), purged the solvent with nitrogen for 5 minutes, and sealed the tube. To the tube was added 4-chloro-N-(4-(7-methoxy-1,5-naphthyridin-4-ylthio)phenyl)phthalazin-1-amine (0.150 g, 0.336 mmol), tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (0.125 g, 0.404 mmol) and sodium carbonate (2.0 M aqueous) (0.336 mL, 0.673 mmol). The mixture was purged with nitrogen, sealed, and then to it was added PdCl2(dppf) (0.012 g, 0.017 mmol). The mixture was again purged with nitrogen, sealed, and heated to 100° C., while stirring for 3 hours. The reaction was cooled to RT and concentrated. The crude material was purified by Isco silica gel chromatography using 0-100% CH2Cl2:MeOH(90:110)/CH2Cl2. The product containing fractions were concentrated to yield tert-butyl 4-(4-(4-(7-methoxy-1,5-naphthyridin-4-ylthio)phenylamino)phthalazin-1-yl)-5,6-dihydropyridine-1(2H)-carboxylate as light yellow solid. MS: [M+H]=593.0; Calc'd 592.7 for C33H32N6O3S.

1. customIn a 20 mL sealed tube
2. custompurged the solvent with nitrogen for 5 minutes
3. customsealed the tube
4. customThe mixture was purged with nitrogen
5. customsealed
6. customThe mixture was again purged with nitrogen
7. customsealed
8. temperatureThe reaction was cooled to RT
9. concentrationconcentrated
10. customThe crude material was purified by Isco silica gel chromatography
11. additionThe product containing fractions
12. concentrationwere concentrated