反应详情

0.6 g (1.8 mmol) of ethyl 3-[3-(4-cyanophenyl)propionylamino]-4-formylbenzoate and 10 mL of methanolic ammonia solution were agitated in a pressure vessel for 36 hours. Then the solvent was distilled off, the residue was chromatographed on silica gel and eluted with methylene chloride containing 0 to 1% methanol. Yield: 0.35 g (62% of theory); Rf value: 0.38 (silica gel, ethyl acetate/cyclohexane=1:1).

1. distillationThen the solvent was distilled off
2. customthe residue was chromatographed on silica gel
3. washeluted with methylene chloride containing 0 to 1% methanol