Potassium Hydroxide → HCID 16115119, compound

HRID 503671Notes

Reaction equation

HRID 503671 reaction equation
[CH3:1][S:2]([O:5][CH2:6][CH2:7][N:8]([CH2:25][CH2:26][O:27][S:28]([CH3:31])(=[O:30])=[O:29])[C:9]1[C:10]([N+:22]([O-:24])=[O:23])=[CH:11][C:12]([N+:19]([O-:21])=[O:20])=[C:13]([CH:18]=1)[C:14]([O:16]C)=[O:15])(=[O:4])=[O:3].[OH-].[K+]>O1CCOCC1>[CH3:31][S:28]([O:27][CH2:26][CH2:25][N:8]([CH2:7][CH2:6][O:5][S:2]([CH3:1])(=[O:4])=[O:3])[C:9]1[C:10]([N+:22]([O-:24])=[O:23])=[CH:11][C:12]([N+:19]([O-:21])=[O:20])=[C:13]([CH:18]=1)[C:14]([OH:16])=[O:15])(=[O:29])=[O:30]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 10051057HCID 10051057, compound

Product 1

HCID 16115119HCID 16115119, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Hydrolysis of 7 (3.0 g, 6.18 mmol) with 3 N KOH (40 mL) in dioxane (200 mL) at room temperature for 15 min followed by acidification with 1N HCl and extraction with EtOAc gave a quantitative yield of 5-(bis{2-[(methylsulfonyl)oxy]ethyl}amino)-2,4-dinitrobenzoic acid (8), mp 200-210° C., which was used for the next step without further purification;

Workup

  1. extractionfollowed by acidification with 1N HCl and extraction with EtOAc

Sources & evidence

ORD record
ord-e160c4c6ec6a4833ac9825de22de172d
Source dataset
uspto-grants-2010_08
Patent number
US07776924B2

Reaction notes

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