Lithium Bromide → HCID 11283100, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 9a (1.80 g, 3.50 mmol) and LiBr (0.43 g, 4.95 mmol) in DMF (5 mL) was stirred at 60° C. for 2 h. The reaction was then poured into saturated NaBr solution and extracted with EtOAc (2×). The combined extracts were washed with saturated NaBr solution, dried (Na2SO4) and concentrated under reduced pressure. The residue was chromatographed on silica gel, eluting with EtOAc, to give 5-[bis(2-bromoethyl)amino]-N-(2-hydroxyethyl)-2,4-dinitrobenzamide (10a) (0.78 g, 46%):

Provenance & Evidence