反应详情

0.823 g (3.14 mmol) of the compound from Example 4A are dissolved in 10 ml of dichloromethane at RT, and 0.688 mg (3.77 mmol) of 2-phenylbutyryl chloride and 0.298 mg (3.77 mmol) of pyridine are added. The mixture is stirred at RT over after. Ethyl acetate is added, and the mixture is extracted with water. The organic phases are dried over magnesium sulfate and freed of solvent under reduced pressure. The residue is purified by chromatography on a silica gel column (mobile phase ethyl acetate:cyclohexane 2:1). 0.943 g (72% of theory) of product are obtained.

1. extractionthe mixture is extracted with water
2. dry with materialThe organic phases are dried over magnesium sulfate
3. customThe residue is purified by chromatography on a silica gel column (mobile phase ethyl acetate:cyclohexane 2:1)
4. custom0.943 g (72% of theory) of product are obtained