HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 2-(1-Benzothien-2-yl)-5-{[2-(1,3-thiazol-2-yl)butanoyl]amino}benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 2-(1-Benzothien-2-yl)-5-[(2-bromobutanoyl)amino]benzamide | HCID 59428488 | — |
| Reactant | HCID 68691917 | HCID 68691917 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(1-Benzothien-2-yl)-5-{[2-(1,3-thiazol-2-yl)butanoyl]amino}benzamide | HCID 59428490 | — |
Reaction Steps
Sodium 2-(2-thiazolyl)propionate (148 mg) is introduced into DMF (5 ml), and 2-(1-benzothien-2-yl)-5-[(2-bromobutanoyl)amino]benzamide (Example 8A; 171 mg), HATU (291 mg) and 4-methylmorpholine (194 mg) are added. The reaction mixture is stirred at RT overnight. The reaction mixture is concentrated and the residue is purified by preparative HPLC. 101 mg (36% of theory) of product are isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07776922B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-c4c998269c044ed584b44de529612a0f |
| Source note | uspto-grants-2010_08 |