Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → 3-Chloro-4-[(1,3-thiazol-2-yl)methoxy]aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 2-((2-Chloro-4-nitrophenoxy)methyl)thiazole | HCID 53401006 | — |
| 촉매 | Zinc | HCID 23994 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-Chloro-4-[(1,3-thiazol-2-yl)methoxy]aniline | HCID 53401110 | 85% |
반응 단계
3-Chloro-4-(thiazol-2-ylmethoxy)-phenylamine is prepared by added Zn dust (55.9 g, 856 mmol) to a mixture of 2-(2-chloro-4-nitro-phenoxymethyl)-thiazole (47.0 g, 190 mmol) in 5:1 MeOH:saturated aqueous NH4Cl solution (600 ml). After 2 h, the reaction mixture is filtered, and the filtrate concentrated. The resulting solid is triturated with water to give 3-chloro-4-(thiazol-2-ylmethoxy)-phenylamine (35.2 g, 85%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07777032B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-10a9c8a830b848df83d806561d75c8d7 |
| 출처 메모 | uspto-grants-2010_08 |