Tetrafluoroborate → 4-(3-Fluoro-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

500 mg 4-(6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde (prepared as described under example 1) and 880 mg 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate are dissolved in 25 ml chloroform and heated under microwave irradiation to 120° C. After for 45 min and 4 h additional portions of 200 mg of 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate are added and heating continued at 120° C. The reaction is worked up after 5 h by diluting with water and extraction with dichloromethane. The combined organic layers are dried over Na2SO4 and the solvens evaporated. The crude material is purified on silica gel (dichloromethane/ethyl acetate.

Herkunft & Nachweise