HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 7-chloro-N-methyl-6-phenylimidazo[1,2-a]pyrimidin-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 5,7-Dichloro-6-phenylimidazo[1,2-a]pyrimidine | HCID 86213633 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-chloro-N-methyl-6-phenylimidazo[1,2-a]pyrimidin-5-amine | HCID 86630660 | — |
Reaction Steps
850 mg 5,7-dichloro-6-phenylimidazo[1,2-a]pyrimidine (prepared as described for example 1) is dissolved in 18 ml of a 8M Solution of MeNH2 in methanol and stirred at room temperature for 1.5 h. The product precipitates upon dilution with water and cooling to 0° C. The solid material is collected by filtration and washed twice with water to yield the desired material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07776864B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-184a8489cdac4a6eae8641de2d7db552 |
| Source note | uspto-grants-2010_08 |