関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trimethyl((tributylstannyl)ethynyl)silane | HCID 639663 | — |
| 反応物 | 4-(3-Bromo-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde | HCID 86630658 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | HCID 86630662 | HCID 86630662 | — |
反応手順
400 mg 4-(3-bromo-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde (prepared as described under example 11), 820 mg trimethyl[(tributylstannyl)ethynyl]silane and 60 mg Pd(PPh3)4 are suspended in 8 ml toluene under a nitrogen atmosphere. The mixture is heated (microwave) to 130° C. for 1 h. The solvent is evaporated and the crude product is purified by column chromatography (dichloromethane/methanol)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07776864B2 |
|---|
| 出典データセット | uspto-grants-2010_08 |
|---|
| ORD ID | ord-195a24bfc5034691b750a2d37a1eaa5c |
|---|
| 出典メモ | uspto-grants-2010_08 |
|---|
