HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 503736Generated: October 25, 2026
Potassium Carbonate → 4-(6-Phenyl-3-vinylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde
https://huagongshe.com/reaction/503736
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Tributylvinyltin | HCID 81998 | — |
| Reactant | 4-(3-Bromo-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde | HCID 86630658 | — |
| Catalyst | Tetraethylammonium Chloride | HCID 5946 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(6-Phenyl-3-vinylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde | HCID 86630663 | — |
Reaction Steps
500 mg 4-(3-bromo-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde (prepared as described under example 11), 180 mg K2CO3, 215 mg Et4NCl, 25 mg PdCl2(PPh3)2 and 620 mg tributyl(vinyl)stannane are suspended in 10 ml THF. The mixture is heated to 110° C. for 45 min. This mixture is worked up by diluting with water and extraction with dichloromethane. The organic layers are dried over Na2SO4 and concentrated to yield the crude product, which is purified by chromatography on silica gel (ethyl acetate/dichloromethane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07776864B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-f13b20a0bc74455bab5624db92227678 |
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| Source note | uspto-grants-2010_08 |
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