Water → HCID 86630675, compound

HRID 503760Notes

Reaction equation

HRID 503760 reaction equation
Cl.[C:2]1([C:8]2[C:9]([C:17]3[CH:22]=[CH:21][C:20]([CH2:23]N4CCC(C5N=C(C6C=CC=CN=6)NN=5)CC4)=[CH:19][CH:18]=3)=[N:10][C:11]3[N:12]([N:14]=[CH:15][CH:16]=3)[CH:13]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:41]N1C(=O)CCC1=O.[OH2:49]>C(Cl)(Cl)Cl.ClCCl>[Br:41][C:16]1[CH:15]=[N:14][N:12]2[CH:13]=[C:8]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:9]([C:17]3[CH:22]=[CH:21][C:20]([CH:23]=[O:49])=[CH:19][CH:18]=3)=[N:10][C:11]=12

Participants

6

Reactant 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 178477949HCID 178477949, compound

Product 1

HCID 86630675HCID 86630675, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6344DichloromethaneSolvent

Procedure

1.0 g 6-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzaldehyde (prepared as described under example 19) and 0.65 g N-bromosuccinimide are refluxed in 30 ml Chloroform for 5 h. This mixture is worked up by diluting with water and extraction with dichloromethane. The organic layers are dried over Na2SO4 and concentrated to yield the crude product, which is suspended in ethyl acetate/petrol ether. The solid desired product is isolated by filtration.

Workup

  1. dry with materialThe organic layers are dried over Na2SO4
  2. concentrationconcentrated
  3. customto yield the crude product, which

Sources & evidence

ORD record
ord-4af5865b1e3546398a0a95d728f38d50
Source dataset
uspto-grants-2010_08
Patent number
US07776864B2

Reaction notes

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