Tetrahydrofuran → HCID 86630678, compound

Participants

Reaction Steps

400 mg 4-(3-bromo-6-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzaldehyde (prepared as described under example 31), 504 mg tributyl(vinyl)stanane, 176 mg tetraethylammonium chloride, 147 mg K2CO3 and 19 mg Pd(PPh3)2Cl2 are suspended in 10 ml THF under a nitrogen atmosphere. The mixture is heated (microwave irradiation) to 110° C. for 45 min. This mixture is worked up by diluting with water and extraction with dichloromethane. The combined organic layers are dried over Na2SO4 and concentrated to yield the crude product, which is purified by chromatography on silica gel (ethyl acetate/dichloromethane).

Provenance & Evidence