Potassium Phosphate, Tribasic → HCID 86630682, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 0.50 g 4-(3-bromo-6-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzaldehyde (prepared as described under example 31) and 0.12 g methylboronic acid in 17 ml toluene are added 0.83 g potassium phosphate tribasic, 0.029 g palladium acetate and 0.11 g S-PHOS. The reaction mixture is heated for 1 h under microwave irradiation to 120° C. This mixture is worked up by diluting with water and extraction with dichloromethane. The organic layers are dried over Na2SO4 and concentrated to yield the crude product, which is purified by chromatography on silica gel (ethyl acetate/dichloromethane).

Provenance & Evidence