Sodium Carbonate → HCID 86630684, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 1.25 g 5-chloro-2,7-dimethyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidine and 0.87 g 4-formylphenylboronic acid in 25 ml 1,2-dimethoxyethane are added 0.18 g dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloromethane adduct and 9.30 ml of a 10% w/w sodium carbonate solution. The resulting mixture is heated to 110° C. by microwave irradiation under an inert gas atmosphere for 45 min. The work up is performed by diluting the reaction mixture with water and dichloromethane, separating the phases and extraction of the aqueous phase with dichloromethane. The combined organic layers are dried over sodium sulphate and the solvent is evaporated. The residue is purified by chromatography on silica gel (dichloromethane/methanol). The desired product is suspended in ethyl acetate/petrolether and isolated by filtration.

Provenance & Evidence