HCID 178498471, compound → Methyl 5-amino-1H-pyrazole-3-carboxylate

HRID 503807Notes

Reaction equation

HRID 503807 reaction equation
[N+:1]([C:4]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[NH:6][N:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[NH:6][N:5]=1

Participants

4

Reactant 1

HCID 178498471HCID 178498471, compound

Product 1

HCID 18445864Methyl 5-amino-1H-pyrazole-3-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 14.0 g methyl 3-nitro-1H-pyrazole-5-carboxylate in 200 ml methanol are added 1.2 g Pd/C (10% w/w). The mixture is stirred under H2-atmosphere at room temperature for 18 h. The mixture is filtrated over kieselgur. The filtrate is concentrated and the crude product is used without further purification.

Workup

  1. filtrationThe mixture is filtrated over kieselgur
  2. concentrationThe filtrate is concentrated
  3. customthe crude product is used without further purification

Sources & evidence

ORD record
ord-14c9a9a466c94fd7a85eadc43ac130ca
Source dataset
uspto-grants-2010_08
Patent number
US07776864B2

Reaction notes

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