Benzophenone imine → HCID 59428634, compound

Participants

Reaction Steps

A 25-mL round-bottomed flask equipped with magnetic stirrer and reflux condenser is charged with rac-2,2′-bis(diphenylphosphino)-1,1′-binapthyl (0.040 g, 0.063 mmol), Pd2dba3 (0.019 g, 0.021 mmol) and sodium tert-butoxide (0.282 g, 2.94 mmol). The reaction vessel is then purged with a stream of nitrogen for 0.5 h. After such time, a solution of Compound 1b (0.600 g, 2.10 mmol) in toluene (6 mL) followed by benzophenone imine (0.45 g, 2.51 mmol) is added. The reaction is then heated at reflux for 2 h. After such time the reaction is cooled to room temperature and concentrated under reduced pressure. The resulting oil is then purified by column chromatography to afford Compound 1c as a yellow oil.

Provenance & Evidence