3-(Trifluoromethyl)-4-methylphenyl Isocyanate → 1-(5-Methyl-1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-3-(4-methyl-3-trifluoromethyl-phenyl)-urea

Beteiligte Stoffe

Reaktionsschritte

Compound 2d (100 mg, 0.42 mmol) is weighed into a round bottom flask and dissolved in dichloromethane (3 mL). 4-Isocyanato-1-methyl-2-trifluoromethyl-benzene (85 mg, 0.42 mmol) is added as a solid and the homogeneous mixture is stirred for 4 h. The precipitate is collected via filtration and the solids are washed with ether and collected to yield compound 2h as a white amorphous solid.

Herkunft & Nachweise