4-Nitro-1-(pyridin-4-yl)methyl-1H-benzimidazole → 1-(Pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine

HRID 503838Notes

Reaction equation

HRID 503838 reaction equation
C[C:2]1[CH:17]=[CH:16][C:5]2[N:6]([CH2:9][C:10]3[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=3)[CH:7]=[N:8][C:4]=2[C:3]=1[NH2:18].[N+](C1C2N=CN(CC3C=CN=CC=3)C=2C=CC=1)([O-])=O>>[N:13]1[CH:14]=[CH:15][C:10]([CH2:9][N:6]2[C:5]3[CH:16]=[CH:17][CH:2]=[C:3]([NH2:18])[C:4]=3[N:8]=[CH:7]2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 594286314-Nitro-1-(pyridin-4-yl)methyl-1H-benzimidazoleHCID 594286405-Methyl-1-(pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine

Product 1

HCID 594286291-(Pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine

Procedure

Using the same general procedure as described above for the preparation of 5-methyl-1-(pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine (2d), reduction of 4-nitro-(1-pyridin-4-yl)methyl-1H-benzimidazole 3c (1.71 g) gave 3d as a pale yellow powder.

Sources & evidence

ORD record
ord-1ec818230ef049d8b4a1145b42093702
Source dataset
uspto-grants-2010_08
Patent number
US07777040B2

Reaction notes

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