Sodium Hydroxide → HCID 18412621, compound

HRID 50384Notes

Reaction equation

HRID 50384 reaction equation
[ClH:1].[C:2]1([N:8]([CH2:31][CH2:32][C:33]([O:35]CC)=[O:34])[C:9]([C:11]2[S:30][C:14]3[N:15]=[C:16]([CH2:19][NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27](=[NH:29])[NH2:28])=[CH:23][CH:22]=4)[N:17]([CH3:18])[C:13]=3[CH:12]=2)=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[ClH:1].[C:2]1([N:8]([CH2:31][CH2:32][C:33]([OH:35])=[O:34])[C:9]([C:11]2[S:30][C:14]3[N:15]=[C:16]([CH2:19][NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27](=[NH:28])[NH2:29])=[CH:23][CH:22]=4)[N:17]([CH3:18])[C:13]=3[CH:12]=2)=[O:10])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18412312HCID 18412312, compound

Product 1

HCID 18412621HCID 18412621, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to Example 2 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]thieno[2,3-d]imidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride and sodium hydroxide solution. Yield: 85% of theory, C24H24N6O3S (476.56); Rf value: 0.36 (Reversed Phase silica gel RP-8; methanol+5% saline solution); EKA mass spectrum: (M+H)+=477; (M+Na)+=499; (M+2Na)++=250.

Sources & evidence

ORD record
ord-fb60e0476f9d4092a67606c11dac06c8
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

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