4-(Chloromethyl)quinoline--hydrogen chloride (1/1) → 4-(4-Nitro-benzoimidazol-1-ylmethyl)-quinoline

HRID 503840Notes

Reaction equation

HRID 503840 reaction equation
[N+:1]([C:4]1[C:12]2[N:11]=[CH:10][N:9]([CH2:13][C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)[C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.Cl[CH2:22][C:23]1C2C(=CC=CC=2)N=[CH:25][CH:24]=1>>[N+:1]([C:4]1[C:12]2[N:11]=[CH:10][N:9]([CH2:13][C:14]3[C:19]4[C:18](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:17]=[CH:16][CH:15]=3)[C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 230016194-(Chloromethyl)quinoline--hydrogen chloride (1/1)HCID 594286314-Nitro-1-(pyridin-4-yl)methyl-1H-benzimidazole

Product 1

HCID 594286394-(4-Nitro-benzoimidazol-1-ylmethyl)-quinoline

Procedure

Compound 4a was synthesized in the same manner as compound 3c using 4-chloromethylquinoline hydrochloride instead of 4-chloromethylpyridine hydrochloride.

Sources & evidence

ORD record
ord-11265e36138f4e3fa6b5097f48bfb79f
Source dataset
uspto-grants-2010_08
Patent number
US07777040B2

Reaction notes

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