4-(Chloromethyl)quinoline--hydrogen chloride (1/1) → 4-(5-Methyl-4-nitro-benzoimidazol-1-ylmethyl)-quinoline

HRID 503841Notes

Reaction equation

HRID 503841 reaction equation
[CH3:1][C:2]1[CH:17]=[CH:16][C:5]2[N:6]([CH2:9][C:10]3[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=3)[CH:7]=[N:8][C:4]=2[C:3]=1[N+:18]([O-:20])=[O:19].Cl.Cl[CH2:23][C:24]1C2C(=CC=CC=2)N=[CH:26][CH:25]=1>>[CH3:1][C:2]1[CH:17]=[CH:16][C:5]2[N:6]([CH2:9][C:10]3[C:11]4[C:12](=[CH:23][CH:24]=[CH:25][CH:26]=4)[N:13]=[CH:14][CH:15]=3)[CH:7]=[N:8][C:4]=2[C:3]=1[N+:18]([O-:20])=[O:19]

Participants

3

Reactant 2

HCID 230016194-(Chloromethyl)quinoline--hydrogen chloride (1/1)HCID 594286355-Methyl-4-nitro-1-(pyridin-4-yl)methyl-1H-benzimidazole

Product 1

HCID 594286324-(5-Methyl-4-nitro-benzoimidazol-1-ylmethyl)-quinoline

Procedure

Compound 5a was synthesized in the same manner as compound 2c using 4-chloromethylquinoline hydrochloride instead of 4-chloromethylpyridine hydrochloride.

Sources & evidence

ORD record
ord-767af711c58e4098b8659b92418ff1fc
Source dataset
uspto-grants-2010_08
Patent number
US07777040B2

Reaction notes

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