Ammonium Chloride → HCID 59428415, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (4-bromo-2-methyl-phenyl)-methanol (46.65 g, 0.2320 mol) in DCM (500 mL) at −15° C. was added mesyl chloride (20.65 mL, 0.2668 mol) followed by TEA (37.04 mL, 0.2668 mol). The reaction was stirred at −15° C. for 1.5 hour. A saturated solution of NH4Cl was then added at −15° C. and the resulting mixture was extracted with DCM. The organic phase was dried over MgSO4, filtered, and concentrated under reduced pressure to afford methanesulfonic acid 4-bromo-2-methyl-benzyl ester as a white solid in quantitative yield (65 g), which was used directly in step 3 without further purification.

Provenance & Evidence