Sodium ethanethiolate → HCID 24984324, compound

Participants

Reaction Conditions

Reaction Steps

Sodium ethanethiolate (94 mg, 1.111 mmol) was added to a solution of 3-[4-(4-methoxy-benzenesulfonyl)-2-methyl-phenyl]-1-methyl-pyrrolidine (128 mg, 0.3705 mol) in DMF (2 mL) and the reaction mixture was heated at 100° C. for 4 hours. The solvent was evaporated under reduced pressure and the residue was purified via flash chromatography (DCM/MeOH/NH4OH) to give 4-[3-methyl-4-(1-methyl-pyrrolidin-3-yl)-benzenesulfonyl]-phenol as a white foam. The free amine was transformed in the corresponding hydrochloride (white foam) by addition of a small excess of HCl in 1,4-dioxane: MP=186.0-187.5° C.

Provenance & Evidence