Sodium Sulfate → HCID 59428434, compound

Participants

Reaction Steps

A solution of LAH (1.0 M in THF, 0.51 mL) was added to a solution of {3-[4-(3-hydroxy-benzenesulfonyl)-2-methyl-phenyl]-pyrrolidin-1-yl}-acetic acid tert-butyl ester (85 mg, 0.2036 mmol) in THF (1 mL). The reaction mixture was stirred at reflux for 2 hours, it was cooled to room temperature and Na2SO4. 10H2O was added. The mixture was filtered and the filtrate was evaporated under reduced pressure. The residue was purified via flash chromatography (DCM/MeOH/NH4OH) to give 42 mg of 3-[3-methyl-4-(1-methyl-pyrrolidin-3-yl)-benzenesulfonyl]-phenol as a white foam: MS (M+H)=332.

Provenance & Evidence