HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethylbenzoyl chloride → ethyl 3-[[2-[[4-[N-(4-ethylbenzoyl)carbamimidoyl]anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethylbenzoyl chloride | HCID 85368 | — |
| Reactant | Ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo(d)imidazole-5-carboxamido)propanoate hydrochloride | HCID 18412337 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | ethyl 3-[[2-[[4-[N-(4-ethylbenzoyl)carbamimidoyl]anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate | HCID 140409611 | 64% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and 4-ethylbenzoylchloride. Yield: 64% of theory, C36H37N7O4 (631.7); Rf value: 0.78 (silica gel; dichloromethane/methanol=9:1); EKA mass spectrum: (M+H)+=632; (M+H+Na)++=327.8; (M+Na)+=654.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-3f9d05a036134b088ef1ed720118172a |
| Source note | uspto-grants-2004_03 |