Methylamine → HCID 66877038, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-[4-(3-fluoro-benzenesulfonyl)-2-methoxycarbonylmethoxy-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (120 mg, prepared as described in Example 13) and methylamine (2M in THF, 1.2 mL) was heated at 90° C. in a sealed tube for 16 hours. The reaction mixture was cooled and concentrated under reduced pressure, and the crude residue was purified via flash chromatography (hexane/EtOAc, 3/7) to give 109 mg of 3-[4-(3-fluoro-benzenesulfonyl)-2-methylcarbamoylmethoxy-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester as a colorless oil.

Provenance & Evidence