Water → HCID 24984813, compound

Participants

Reaction Steps

Lithium alluminiumhydride (1.0 M in THF, 0.51 mL) was added to a solution of {3-[4-(3-fluoro-benzenesulfonyl)-2-methyl-phenyl]-pyrrolidin-1-yl}-acetic acid methyl ester (100 mg, 0.2554 mmol) in THF (1 mL) and the resulting mixture was stirred at room temperature for 1 hour. Water was slowly added and the mixture was extracted with DCM. The combined organic extracts were washed with water and brine, dried over Na2SO4, filtered, and evaporated under reduced pressure. The resulting crude material was purified via flash chromatography (DCM/MeOH/NH4OH) to give 7 mg of 2-{3-[4-(3-fluoro-benzenesulfonyl)-2-methyl-phenyl]-pyrrolidin-1-yl}-ethanol, MS (M+H)=364.

Provenance & Evidence