HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 18412599, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | HCID 18412427 | HCID 18412427 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 18412599 | HCID 18412599 | 19% |
Reaction Steps
Prepared analogously to Example 25d from 1-methyl-2-[N-(2-cyanopyrazin-5-yl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide and ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 19% of theory, C25H27N9O3 (501.6); Rf value: 0.28 (silica gel; dichloromethane/methanol=4:1+1% glacial acetic acid); EKA mass spectrum: (M+H)+=502; (M+H+Na)+=262.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-cd57f0848bde4d88a718a22cefba4489 |
| Source note | uspto-grants-2004_03 |