反应详情

To a dichloromethane (20 ml) solution of 1.00 g (0.00243 mM) of 5-[1-(4-aminobenzyl)-8-methoxy-2-oxo-1,2,3,4-tetrahydroquinolin-5-ylmethyl]thiazolidine-2,4-dione were successively added pyridine (2.0 ml) and 0.21 ml (0.0027 mM) of methanesulfonyl chloride under ice cooling with stirring. The mixture was stirred at the same temperature for 30 minutes, and water was added to stop the reaction. The resultant was washed (twice with water and once with saturated sodium chloride solution), dried (magnesium sulfate), and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane:ethyl acetate=1:10→1:1), giving 1.1 g (92% yield) of the target compound as a white amorphous solid.

1. stirringThe mixture was stirred at the same temperature for 30 minutes
2. customthe reaction
3. washThe resultant was washed (twice with water
4. dry with materialonce with saturated sodium chloride solution), dried (magnesium sulfate)
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by silica gel column chromatography (dichloromethane:ethyl acetate=1:10→1:1)