反应详情

温度

140 °C

8.3 g of potassium pentafluoropropionate and 9.8 g of CuI are introduced into a 500 ml three-necked flask equipped with Dean-Stark apparatus and a condenser, under an inert atmosphere. 90 ml of DMF and 110 ml of toluene are added. The medium is heated to 140° C. under nitrogen and 80 ml of toluene are distilled off. The medium is then cooled to RT and then deoxygenated by sparging with nitrogen. 6 g of iodoanisole are then added, followed by heating at 155° C. for 20 hours. After cooling to RT, the medium is diluted with 200 ml of a water/ethyl ether mixture. The medium is then filtered through Celite®. The organic phase is washed 3 times with water, dried over MgSO4 and then evaporated to give 4.3 g of a brown oil.

1. customequipped with Dean-Stark apparatus and a condenser, under an inert atmosphere
2. distillation80 ml of toluene are distilled off
3. temperatureThe medium is then cooled to RT
4. customdeoxygenated
5. customby sparging with nitrogen
6. addition6 g of iodoanisole are then added
7. temperatureby heating at 155° C. for 20 hours
8. temperatureAfter cooling to RT
9. additionthe medium is diluted with 200 ml of a water/ethyl ether mixture
10. filtrationThe medium is then filtered through Celite®
11. washThe organic phase is washed 3 times with water
12. dry with materialdried over MgSO4
13. customevaporated