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HRID 50407作成日：2026年10月25日

Carbonochloridic acid, heptyl ester → ethyl 3-(N-[2-[[4-(N-heptoxycarbonylcarbamimidoyl)-2-methoxyanilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate

https://huagongshe.com/reaction/50407

反応式

関与物質

役割名称HCID仕込み量
反応物Carbonochloridic acid, heptyl esterHCID 118547—
反応物1-Methyl-2-[-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochlorideHCID 18412296—
溶媒Dichloromethane ethanolHCID 21584144—
生成物ethyl 3-(N-[2-[[4-(N-heptoxycarbonylcarbamimidoyl)-2-methoxyanilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoateHCID 14040960468%

反応手順

Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-heptyl chloroformate. Yield: 68% of theory, C37H46N6O6 (670.8); Rf value: 0.56 (silica gel; dichloromethane/ethanol=9:1); EKA mass spectrum: (M+H)+=671; (M+H+Na)++=347.4.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06710055B2
出典データセットuspto-grants-2004_03
ORD IDord-e9a0fedd15fc4cf6bf35d67e5e21545a
出典メモuspto-grants-2004_03