HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonochloridic acid, heptyl ester → ethyl 3-[[2-[[4-(N-heptoxycarbonylcarbamimidoyl)-2-methoxyanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonochloridic acid, heptyl ester | HCID 118547 | — |
| Reactant | 1-methyl-2-[N-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride | HCID 18412588 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | ethyl 3-[[2-[[4-(N-heptoxycarbonylcarbamimidoyl)-2-methoxyanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate | HCID 140409615 | 55% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-heptyl chloroformate. Yield: 55% of theory, C36H45N7O6 (671.8); Rf value: 0.54 (silica gel; dichloromethane/ethanol=9:1); EKA mass spectrum: (M+H)+=672; (M+H+Na)++=347.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-2c5813e1c483436dbb4dbe6d0ac204a8 |
| Source note | uspto-grants-2004_03 |