2-Bromo-3-Dodecylthiophene → HCID 59428851, compound

Participants

Reaction Steps

A reaction between 2-bromo-3-dodecylthiophene (Compound-1, 81.0 mmol) and excess copper cyanide (CuCN) produced 2-cyano-3-dodecylthiophene (Compound-2, 34% yield), which was heated and reacted with excess (approximately 2.5 equivalents) dithiophosphoric acid O,O′-diethylether in tetrahydrofuran (THF) solution for about 12 hours. The obtained 2-thioamino-3-dodecylthiophene (Compound-3, 45% yield) and 1.2 equivalents of bromooctanone were reacted to obtain 2-thiazole(3′-dodecyl)-3-dodecylthiophene (Compound-4, 32% yield), which was in turn reacted with N-bromosuccinimide (NBS) to obtain the thiophene-thioazol derivative (Compound-5, 82% yield). An NMR analysis result of the resultant product was as follows:

Provenance & Evidence