HCID 59428662, compound → HCID 16773932, compound

Participants

Reaction Steps

A mixture of (S)-1-(3-fluoro-benzenesulfonyl)-piperidine-2-carboxylic acid benzyl ester (6.51 g, 17.3 mmol), ethanol (200 mL) and 10% Pd on carbon (1.83 g, 1.70 mmol) was hydrogenated at 30 psi for 3 h. The suspension was then filtered through celite and washed with ethyl acetate. The filtrate was concentrated under reduced pressure. The resulting oil was chromatographed on silica gel (dichloromethane/n-heptane, 9/1) to afford 4.10 g (82.9%) of the title compound.

Provenance & Evidence