(1S)-(+)-Camphor-10-sulphonic acid → (1R)-1'-{[1-(6-Phenylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3'-pyrrolidin]-3-one

Participants

Role	Name	HCID	Charge
Reactant	(1S)-(+)-Camphor-10-sulphonic acid	HCID 218580	—
Reactant	(1R)-3H-spiro[2-benzofuran-1,3'-pyrrolidin]-3-one	HCID 57989403	—
Reactant	HCID 66661648	HCID 66661648	—
Product	(1R)-1'-{[1-(6-Phenylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3'-pyrrolidin]-3-one	HCID 66662296	—

Reaction Steps

1-(6-Phenylpyridin-3-yl)cyclopropanecarboxylic acid was then coupled with (1S)-(+)-10-camphorsulfonic acid salt of (1R)-3H-spiro-[2-benzofuran-1,3′-pyrrolidin]-3-one using procedures analogous to those of Example 83 to afford (1R)-1′-{[1-(6-Phenylpyridin-3-yl)cyclopropyl]carbonyl}-3H-spiro[2-benzofuran-1,3′-pyrrolidin]-3-one. MS (ESI): (M+H)+=411.1

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07776874B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-b2901d20b4354ad88eace1593f496d7f
Source note	uspto-grants-2010_08