HRID50431

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10680096

未命名化合物

结构：CCc1nc2c(C)cc(C)nc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(-c3ccccc3)cc2)cc1

HCID21875619

未命名化合物

PRODUCTS

生成物

结构：CCc1nc2c(C)cc(C)nc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2cc3ccccc3s2)cc1

HCID21876088

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in step 2 of Example 18 from phenyl 2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethylcarbamate (step 1 of Example 18) and 1-benzothiophene-2-sulfonamide (Chern, J.; Leu, Y.; et al. J. Med. Chem., 1997, 40, 2276.; Graham, S. L.; Shepard, K. L.; et al. J. Med. Chem., 1989, 32, 2548).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9d50be13a3e940608273703fb17d0e18
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06710054B2
来源说明: uspto-grants-2004_03

反应 SMILES

C1(C2C=CC=CC=2)C=C[C:4]([S:7]([NH:10][C:11]([NH:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[C:26]4=[N:27][C:28]([CH3:32])=[CH:29][C:30]([CH3:31])=[C:25]4[N:24]=[C:23]3[CH2:33][CH3:34])=[CH:18][CH:17]=2)=[O:12])(=[O:9])=[O:8])=[CH:3]C=1.[S:41]1[C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][C:44]=2C=C1S(N)(=O)=O>>[S:41]1[C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][C:44]=2[CH:3]=[C:4]1[S:7]([NH:10][C:11]([NH:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:26]3=[N:27][C:28]([CH3:32])=[CH:29][C:30]([CH3:31])=[C:25]3[N:24]=[C:23]2[CH2:33][CH3:34])=[CH:18][CH:17]=1)=[O:12])(=[O:9])=[O:8]