反应详情

温度

70 °C

To a mixture of racemic (2′R,3R,4′S)-6-chloro-4′-[5-chloro-2-(1-methoxycarbonyl-cyclobutoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (200 mg, 0.33 mmol) in methanol (4 mL) was added a solution of NaOH (40 mg, 1 mmol) in water (2 mL). The mixture was heated at 70° C. for 2 h, evaporated to remove methanol, cooled to room temperature, and acidified to “pH” 1 with HCl aq. The precipitate was collected, washed with water and dried to give the title compound as a white solid (175 mg).

1. customevaporated
2. customto remove methanol
3. temperaturecooled to room temperature
4. customwas collected
5. washwashed with water
6. customdried