Potassium Phosphate, Tribasic → HCID 74928767, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	4,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolane	HCID 10997426	—
Reactant	HCID 74928745	HCID 74928745	—
Catalyst	HCID 178418397	HCID 178418397	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	HCID 74928767	HCID 74928767	12.7%

Reaction Conditions

Temperature	80 °C

Reaction Steps

To a mixture of racemic (2′S,3S,4′R)-4′-[5-bromo-2-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-6-chloro-2′-(5-chloro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (50 mg, 0.08 mmol), isopropenylboronic acid pinacol ester (40 mg, 0.24 mmol) and K3PO4 (50 mg, 0.24 mmol) in THF was added Pd(PPh3)4 (15 mg). The mixture was heated at 80° C. for 8 h under an argon atmosphere, purified by prep-HPLC to give the title compound as a white solid (6 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07776875B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-f28a86770f22439e8a83f78cb1806129
Source note	uspto-grants-2010_08