Potassium Phosphate, Tribasic → HCID 86632055, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of racemic (2′S,3S,4′R)-4′-[5-bromo-2-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-6-chloro-2′-(5-chloro-2-methyl-phenyl)-spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (50 mg, 0.08 mmol), trimethylsilylacetylene boronic acid dimethyl ester (0.7 M, 0.7 mL, 0.49 mmol) and K3PO4 (100 mg, 0.48 mmol) in THF was added Pd(PPh3)4 (15 mg) under argon. The reaction mixture was heated at 80° C. for 20 h, purified by prep-HPLC to give the title compound as a white solid.

Provenance & Evidence