Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Reactant | HCID 57750104 | HCID 57750104 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86632058 | HCID 86632058 | 52.9% |
Reaction Steps
To a mixture of 6-chlorooxindole (1.1 g, 6.4 mmol) and 5-chloro-2-(pyrimidin-2-yloxy)-benzaldehyde (1.5 g, 6.4 mmol) in methanol (10 mL) was added pyrrolidine (0.5 mL, 6.4 mmol) dropwise. The mixture was then heated at 70° C. for 3 h. After cooled to 4° C., the mixture was filtered and the precipitate was collected, dried to give the title compound as a bright yellow solid (1.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07776875B2 |
|---|
| Source dataset | uspto-grants-2010_08 |
|---|
| ORD ID | ord-e9025830f63c46b4b08da9dc82a3e886 |
|---|
| Source note | uspto-grants-2010_08 |
|---|
