6-Chloro-3-[5-chloro-2-(pyrimidin-2-yloxy)-benzylidene]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester → 6-chloro-4'-[5-chloro-2-(pyrimidin-2-yloxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Participants

Reaction Steps

In a manner similar to the method described in example 1e, 6-chloro-3-[5-chloro-2-(pyrimidin-2-yloxy)-benzylidene]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (1 g, 2 mmol) was reacted with 1-(5-fluoro-2-methylphenyl)-3-trimethylsilyoxy-2-aza-1,3-butadiene (10 mL, 20 mmol) in toluene to give title compound as a white solid (Yield: 40 mg).

Provenance & Evidence