Water → 6-chloro-4'-[5-chloro-2-(2-hydroxycarbonyl-2-methyl-propoxy)-phenyl]-2'-(5-fluoro-2-methylphenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Participants

Reaction Conditions

Reaction Steps

A mixture of 330 mg racemic (2′R,3R,4′S)-6-chloro-4′-[5-chloro-2-(2-methoxycarbonyl-2-methyl-propoxy)-phenyl]-2′-(5-fluoro-2-methylphenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (330 mg, 0.55 mmol), NaOH (80 mg, 2 mmol), H2O (5 mL) and methanol (10 mL) was heated at 60° C. for 2 h. Then the methanol was removed in vacuum. The water solution was acidified by concentrated hydrochloric acid to “pH” 2. The white precipitate was collected by filtration to give title compound (Yield: 250 mg).

Provenance & Evidence