Tetrahydrofuran → HCID 74928746, compound

Participants

Role	Name	HCID	Charge
Reactant	Tetrahydrofuran	HCID 8028	—
Reactant	2,2,2-Trifluoroethylamine hydrochloride	HCID 9772	—
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Reactant	HCID 77502936	HCID 77502936	—
Product	HCID 74928746	HCID 74928746	—

Reaction Steps

In a manner similar to the method described in Example 27, racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-hydroxycarbonyl-2-methyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (150 mg, 0.263 mmol) was reacted with 2,2,2-trifluoroethylamine hydrochloride (71 mg, 0.526 mmol), EDC.HCl (100 mg, 0.526 mmol), HOBt (71 mg, 0.526 mmol) and DIPEA (204 mg, 1.579 mmol) in anhydrous THF (3 mL) to give title compound as a white solid (50 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07776875B2
Source dataset	uspto-grants-2010_08
ORD ID	ord-fa5af606612343debbe8f4bf6e7bc25b
Source note	uspto-grants-2010_08